Filamentary keratitis is a chronic corneal condition characterized by multiple filaments attached to areas of compromised corneal epithelium. The filaments can be quite extensive and may enmesh calcareous granules, bacteria, and dust particles. Blinking lids pull on the loose ends of the filaments, stimulating the pain-sensitive corneal nerves and creating multiple epithelial defects. Patients often experience foreign body sensation, discomfort, photophobia, pain, and blurry vision. Filamentary keratitis most often accompanies dry eye syndrome and patients may also have underlying systemic conditions, particularly connective tissue disorders. Cryopreserved amniotic membrane contains anti-inflammatory mediators and complex arrays of growth factors and cytokines, which help regenerate a healthy corneal epithelium and may reduce recurrence.