For Surgical Patients

Patient Resource Center

A Message from our Founder and Chief Technology Officer

Dr. Scheffer Tseng, MD, PhD

Did you know…

There are 6.5 MILLION PEOPLE in the U.S. who suffer from deficient chronic wound healing.1 The incidence rate continues to rise due to an aging population and increased risk factors, leading to complications including severe discomfort, infection, and amputations.1

Around 70 MILLION SURGERIES are performed each year — all resulting in wounds — many with comorbidities that may lead to challenging healing.2

OVER $25 BILLION ARE SPENT ANNUALLY on the treatment of chronic wounds.18 There is a growing burden due to an aging population, diabetes, and obesity.18 There are over $13.1 BILLION IN MEDICARE COSTS for non-healing and infected-healing surgical wounds (even greater than the cost of treating diabetic foot ulcers).22

Find a provider near you.

Search our physician directory to find a surgeon near your location.

The way we prepare human birth tissue makes all the difference.

  • Delivers the natural power of human birth tissue to wound environments3
  • Helps manage discomfort, reduce adhesions and promotes a healing environment3-20
  • Promotes higher healing rates compared to Standard of Care6-12,15,16

Bring the natural power of human birth tissue to your surgical patients and discover a paradigm shift in healing and functional recovery.3

Advanced Wound Therapy Beyond Compare

For over 30 years, our pioneering scientists have focused on understanding the regenerative features of human birth tissue—ultimately identifying HC-HA/PTX3 as a key orchestrator in human birth tissue regenerative healing.

The Solution

A comprehensive family of amniotic membrane allografts used as adjunct therapies for the management of regenerative healing and functional recovery of surgical, acute, and chronic wounds.

Discover BioTissue Surgical Products


Cryopreserved human birth tissue allograft

The Neox family of products are used to manage chronic and complex wounds. Neox is designed to meet the needs of clinicians and patients and comes in a variety of sizes, formulations and storage options.


Cryopreserved human birth tissue allograft

Maintaining an active lifestyle after suffering from a debilitating injury or joint disease can be difficult. Clarix has been used extensively in orthopedic surgery procedures ranging from soft-tissue repair to nerve decompression, trauma and reconstruction, and arthroplasty.

Promote Regenerative Healing, Backed by Research

Our extensive research allows us to preserve and deliver the most functional allograft for your needs.


Research & Development


Human Clinical Applications


Peer-Review Publications


Well, 6 weeks ago I couldn’t walk. Today I’m walking a mile!

This is just a miracle to me because I don’t even have pain. The physical therapy was great too. But I’m perfect now!

Catherine F.

He was clearly limping (heavily) and in pain. When I asked what was going on he said his doctor recommended a partial knee replacement, but that he wasn’t going to have surgery because of the COVID risk.

My dad’s doc was able to get him all the info he needed to approve and get my dad the injection. My dad said the pain is much better, he’s not limping and even sleeping better. My mom confirmed that he wasn’t just telling me that. He is truly better and not limping anymore.

Krista R.
Swan J. Use of Cryopreserved, Particulate Human Amniotic Membrane and Umbilical Cord (AM/UC) Tissue: A Case Series Study for Application in the Healing of Chronic Wounds. Surg Technol Int. 2014;25:73‐78.
Sen CK, Gordillo GM, Roy S, et al. Human skin wounds: a major and snowballing threat to public health and the economy. Wound Repair Regen. 2009;17(6):763-771.
Tseng SC. Invest Ophthalmol Vis Sci. 2016;57(5):ORSFh1‐ORSFh8.
He H, Li W, Tseng DY, et al. Biochemical characterization and function of complexes formed by hyaluronan and the heavy chains of inter-alpha-inhibitor (HC*HA) purified from extracts of human amniotic membrane. J Biol Chem. 2009;284:20136-46.
He H, Zhang S, Tighe S, Son J, Tseng SC. Immobilized Heavy Chain-Hyaluronic Acid Polarizes Lipopolysaccharide-activated Macrophages towards M2 Phenotype. J Biol Chem. 2013;288:25792-803
Caputo WJ, Vaquero C, Monterosa A, et al. A retrospective study of cryopreserved umbilical cord as an adjunctive therapy to promote the healing of chronic, complex foot ulcers with underlying osteomyelitis. Wound Repair Regen. 2016;24(5):885-893.
Couture M. A Single-center, Retrospective Study of Cryopreserved Umbilical Cord for Wound Healing in Patients Suffering from Chronic Wounds of the Foot and Ankle. Wounds. 2016;28(7):217-25.
Marston WA, Lantis JC 2nd, Wu SC, et al. An open-label trial of cryopreserved human umbilical cord in the treatment of complex diabetic foot ulcers complicated by osteomyelitis. Wound Repair Regen. 2019;27(6):680-86.
Marston WA, Lantis JC 2nd, Wu SC, et al. One-year Safety, Healing and Amputation Rates of Wagner 3-4 Diabetic Foot Ulcers Treated with Cryopreserved Umbilical Cord (TTAX01). Wound Repair Regen. 2020. Online ahead of print.
Raphael A. A single-centre, retrospective study of cryopreserved umbilical cord/amniotic membrane tissue for the treatment of diabetic foot ulcers. J Wound Care. 2016;25(Sup7):S10-17.
Raphael A, Gonzales J. Use of cryopreserved umbilical cord with negative pressure wound therapy for complex diabetic ulcers with osteomyelitis. J Wound Care. 2017;26(Sup10):S38-44.
Bemenderfer TB, Anderson RB, Odum SM, Davis WH. Effects of Cryopreserved Amniotic Membrane-Umbilical Cord Allograft on Total Ankle Arthroplasty Wound Healing. J Foot Ankle Surg. 2019;58(1):97-102.
DeMill SL, Granata JD, Berlet GC, et al. Safety Analysis of Cryopreserved Amniotic Membrane/Umbilical Cord Tissue in Foot and Ankle Surgery: A Consecutive Case Series of 124 Patients. Surgical Technol Int. 2014;25:257-61.
Ellington J, Ferguson C. The use of amniotic membrane/umbilical cord in first metatarsophalangeal joint cheilectomy: a comparative bilateral case study. Surg Technol Int. 2014;25:63-67.
Garras D, Scott R. Particulate Umbilical Cord/Amniotic Membrane for the Treatment of Plantar Fasciitis. AOFAS Annual Meeting 2017.
Hanselman AE, Tidwell J, Santrock R. Cryopreserved Human Amniotic Membrane Injection for Plantar Fasciitis: A Randomized, Controlled, Double-Blind Pilot Study. Foot Ankle Int. 2015 Feb;36(2):151-8.
Stewart CM. The Use of Cryopreserved Umbilical Cord in Open Reduction and Internal Fixation of Calcaneal Fractures. SunKrist J Trauma Emerg Med Acute Care. 2019;1(1):1-6.
Swan J. Use of Cryopreserved, Particulate Human Amniotic Membrane and Umbilical Cord (AM/UC) Tissue: A Case Series Study for Application in the Healing of Chronic Wounds. Surg Technol Int. 2014;25:73‐78.
Warner M, Lasyone L. An Open-label, Single-center, Retrospective Study of Cryopreserved Amniotic Membrane and Umbilical Cord Tissue as an Adjunct for Foot and Ankle Surgery. Surg Technol Int. 2014;25:251-5.
Papanna R, Moise KJ Jr, Mann LK, et al. Cryopreserved Human Umbilical Cord Patch for In-Utero Spina Bifida Repair. Ultrasound Obstet Gynecol. 2016;47(2):168-76.
Sen CK, Gordillo GM, Roy S, et al. Human skin wounds: a major and snowballing threat to public health and the economy. Wound Repair Regen. 2009;17(6):763-771.
World Union of Wound Healing Societies. Consensus Document. Surgical wound dehiscence: improving prevention and outcomes. Wound International, 2018.
Dua HS, Gomes JA, King AJ, Maharajan VS. The amniotic membrane in ophthalmology. Surv Ophthalmol. 2004;49(1):51-77.
Bouchard CS, John T. Amniotic membrane transplantation in the management of severe ocular surface disease: indications and outcomes. Ocul Surf. 2004;2(3):201-211.
Tseng SC, Espana EM, Kawakita T, et al. How does amniotic membrane work? Ocul Surf. 2004;2(3):177-187.
Data on file.
Lavker RM, Tseng SC, Sun TT. Corneal epithelial stem cells at the limbus: looking at some old problems from a new angle. Exp Eye Res. 2004;78(3):433-46.