For Ocular Patients

Patient Resource Center

BioTissue develops innovative Amniotic Membrane and Umbilical Cord products used by eye care professionals worldwide for the management of a wide range of ocular surface diseases and disorders such as keratitis, dry eye syndrome, recurrent corneal erosion, pterygium, pinguecula, conjunctivochalasis (CCh)/Mechanical Dry Eye(MDE) and chemical burns.

These products incorporate human Amniotic Membrane and Umbilical Cord processed with the Company’s proprietary CryoTek® method that ensures the tissue retains its full biologic activity to reduce inflammation, minimize corneal scarring, and promote growth, collectively promoting a healing environment.

Promote Regenerative Healing, Backed by Research

Our extensive research allows us to preserve and deliver the most functional allograft for your needs.

36Y

Research & Development

680K

Transplants

380

Clinical Publications

Prokera®

Prokera is a combination medical device used by eye doctors around the world for anti-inflammation, anti-scarring and promoting healing of damaged eye surfaces. It contains the only FDA-cleared cryopreserved amniotic membrane, which supports the corneal-healing process without harmful side effects.1,2,3

Patient Resources

  • Prokera Patient Brochure – DOWNLOAD
  • Prokera Patient Brochure (Spanish) – DOWNLOAD
  • Prokera What To Expect Patient Guide – DOWNLOAD
  • Prokera What To Expect Patient Guide (Spanish) – DOWNLOAD

Frequently Asked Questions

What is Prokera?

Prokera is made from amniotic membrane which has natural anti-inflammatory and anti-scarring properties. It is the only FDA-cleared therapeutic device used by eye care practitioners to provide quick1 symptom relief and reduce inflammation associated with ocular surface disease. It helps restore your cornea and return your eye to a normal, healthy state.

What is amniotic membrane tissue?

Amniotic membrane is part of the placenta and is the tissue closest to the baby throughout development in the womb. Amniotic membrane protects the baby from any harm and has natural biologic actions which help the baby develop. The tissue has biological properties that aid in ocular surface repair.

The amniotic membrane tissue in Prokera has natural therapeutic actions that help damaged eye surfaces heal. Eyes treated with Prokera have less scarring and less inflammation. The amniotic membrane in Prokera is thin and clear like the tissue on the surface of your eye and protects your eye’s damaged tissue while inserted.

What does Prokera treat?

Prokera is used by eye doctors to treat eye diseases such as keratitis, corneal scars, chemical burns, corneal defects, partial limbal stem cell deficiency and many other ocular surface diseases with inflammation.

Prokera is provided by a tissue bank regulated by the FDA. The tissue has passed many quality control tests before it is provided to your doctor. Ask your doctor if you are concerned about the risks involved with using a human tissue.

Is Prokera safe?

Prokera is a safe treatment provided by an FDA-regulated tissue bank. The tissue is donated from healthy mothers who have had c-sections. The donor and tissue have passed numerous quality control tests including social habits, physical and medical screening before it is provided to your doctor.

What should you expect?

Prokera is similar to a large contact lens. You may experience awareness of the ring but it is not painful. For optimal healing, it is important that you complete the Prokera treatment period of 3-5 days. Your eye doctor may use tape to partially close your eyelid after PROKERA is inserted.

Special instructions for Prokera:

  • Avoid rubbing your eyes, forceful blinking, or moving Prokera with your fingers
  • Do not remove Prokera without consulting your eye doctor first
  • Do not swim or soak your eye with water
  • Shower only when the eye is tightly closed
  • Do not drive or operate heavy machinery or perform functions that require unobstructed vision or good depth perception
  • Use eye drops and other medications as prescribed by your eye doctor

 

Contact your eye doctor right away if you are uncomfortable or have any other problems with Prokera, such as swelling, redness or discharge.

AmnioGraft®

AmnioGraft is the only amniotic membrane tissue that has been recognized by the FDA for its unique anti-inflammatory, anti-scarring, and anti-angiogenic properties. This tissue is used by eye surgeons around the world to protect, repair, and promote regenerative healing of damaged eye surfaces.

AmnioGraft: “The Gold Standard” for Ocular Surface Reconstruction

AmnioGraft has natural properties that help damaged eye surfaces heal faster. Eyes treated with AmnioGraft have quicker healing, less scarring, and less inflammation. AmnioGraft is thin and clear like the tissue on the surface of your eye. It is used to replace damaged tissue on the surface of your eye and provide protection after surgery.

AmnioGraft is used to help manage symptoms of eye diseases such as corneal defects, partial stem cell deficiency, chemical burns, conjunctivochalasis, pterygium, symblepharon and many other ocular surface conditions.

AmnioGraft is a safe, effective product provided by FDA-regulated tissue bank. The tissue has passed many quality control tests before it is provided to your doctor. AmnioGraft has never been associated with any serious adverse events in the last 20 years of widespread clinical use. Ask your doctor if you are concerned about the risk involved with using human tissue.

Patient Resources

  • AmnioGraft Patient Guide – DOWNLOAD
  • AmnioGraft Mechanical Dry Eye Patient Guide – DOWNLOAD
  • AmnioGraft Pterygium Patient Guide – DOWNLOAD
  • AmnioGraft Pterygium Patient Guide (Spanish) – DOWNLOAD
AmnioGraft

Frequently Asked Questions

What is AmnioGraft?

AmnioGraft is the only cryopreserved amniotic membrane tissue that has been recognized by the FDA for its unique anti-scarring, anti-inflammatory and anti-angiogenic properties.

The tissue is donated by healthy consenting mothers after scheduled cesarean section (C-Section) births within the USA. Donor suitability is stringent and is determined through social, physical, and medical screening.

What is amniotic membrane tissue?

Amniotic membrane is part of the placenta. It is the tissue closest to the baby throughout development in the womb. The biological properties of amniotic membrane protects the baby from any harm and its natural therapeutic actions helps the baby develop.

The placentas used to prepare AmnioGraft are donated by consenting mothers after cesarean section births. Mothers that donate are fully informed, have healthy lifestyles, and are tested against infectious diseases prior to donation.

Is AmnioGraft Safe?

AmnioGraft is a safe, effective product provided by a FDA-regulated tissue bank. AmnioGraft has never been associated with any serious adverse events in the last 20 years of widespread clinical use.

AmnioGuard®

AmnioGuard is the umbilical cord tissue that is thicker and stronger tissue contains amniotic membrane that has been recognized by the FDA for its unique anti-inflammatory, anti-scarring, and anti-angiogenic properties. This tissue is used by eye surgeons around the world to cover the glaucoma shunt tube and to protect, repair, and promote regenerative healing of damaged eye surfaces.

Find a provider near you.

Search our physician directory to find a surgeon near your location.

The way we prepare human birth tissue makes all the difference.

  • Delivers the natural power of human birth tissue to wound environments3
  • Helps manage discomfort, reduce adhesions and promotes a healing environment3-20
  • Promotes higher healing rates compared to Standard of Care6-12,15,16

Bring the natural power of human birth tissue to your surgical patients and discover a paradigm shift in healing and functional recovery.3

Testimonials

As a sales professional and someone who makes their living interacting with the public, I often had people comment my eyes appeared to be red and tired looking. Finally, I reached a point where it was time to address my problem! After doing some research, I concluded there was an “old way” of performing pterygium surgery, and a “newer, more advanced method” using the AmnioGraft. I decided to go for it. Two years later, I could not be happier! The recovery time and healing process was completely uneventful, and my eyes look great!

Mark Hayward

AmnioGraft enables me to prevent inflammation, scarring, promote rapid regenerative healing post-operatively, in a manner not achievable with denatured tissue. AmnioGraft also preserves the cellular architecture of the tissue and hence retains intraoperative resilience, workability, and handling – much like an ‘instant pre-packaged autograft’ — allowing for superior, efficient, and reproducible surgical results.

Neel Desai MD, FL

Dr. Sally Mellgren performed the above procedure [AmnioGraft for Mechanical Dry Eye] on my right eye and on my left eye. I experienced no problems with the recovery from the procedures. My vision and clarity was much improved and I would recommend it for others experiencing the same problems.

Shirley Slentz

For many years, I suffered in pain from my dry eyes which eventually led to a corneal ulcer. My eyes were constantly itchy and red and my vision fluctuated. The treatment with Prokera was quick and simple, and felt similar to a contact lens being inserted. My vision has improved, which is crucial to me as an artist. Prokera has truly changed my quality of life and brought me back to feeling normal again.

Prokera Patient
References
Desai NR. A comparison of cryopreserved amniotic membrane and bandage contact lens in their ability to provide high-quality healing after superficial keractectomy. Rev Ophthalmol. September 2014:1-6
Pachigolla G, Prasher P, Di Pascuale MA, et al. Evaluation of the role of Prokera in the management of ocular surface and orbital disorders. Eye Contact Lens. 2009;35(4):172-175.
Morkin MI, Hamrah P. Efficacy of self-retained cryopreserved amniotic membrane for treatment of neuropathic corneal pain. Ocul Surf. 2018;16(1):132-138.