Super Strength, Powerful Properties.

AmnioGuard® is an ultra-thick, cryopreserved amniotic membrane graft that suppresses inflammation, promotes healing, and provides durable tensile strength to avoid surgical challenges associated with reconstructive procedures.1-4


Seeing a Difference.

Our biologic ocular transplantation tissue grafts help your patients heal better and faster. BioTissue’s CryoTek® cryopreserved amniotic membrane grafts are the only amniotic membrane products cleared by the FDA for their therapeutic properties in repairing and healing ocular surface inflammation.5


AmnioGuard helps achieve complete epithelialization, without wound dehiscence and excellent prosthesis fit at final follow-up with no clinically significant complications.3


AmnioGuard serves as an excellent alternative to other homologous tissue grafts for ocular surface reconstruction and management of Anophthalmic socket contracture.3


AmnioGuard has been shown to help promote superior stability in post-glaucoma treatment and optimal healing in post-oculoplasty surgery.1

Sizing & Specs
  • Sizing & Specs
  • Handling & Storage
  • Applications
  • Resources
  • Customer Support
  • Sizing & Specs
  • Handling & Storage
  • Applications
  • Resources
  • Customer Support

Available sizes

AGD 1075 (1.0 x 0.75 cm)

AGD 2520 (2.5 x 2.0 cm)

AGD GS40 (3.0 x 4.0 cm)

Average thickness: 500-900 µm19

Location & Temperature

-80°C → 4°C (-112°F → 39.2°F)

Example: ultra-low temperature freezer, standard freezer, or standard refrigerator

Shelf Life

Within the expiration date printed on product packaging (2 years from date of manufacture)


  • If frozen, allow AmnioGuard to sit at controlled room temperature (20°C to 25°C) inits original unopened packaging for at least 5 minutes.
  • Open the outer foil peel pouch and present the clear inner pouch to the sterile field using aseptic techniques.
  • Open the clear inner peel pouch to retrieve AmnioGuard.
  • Place the tissue on the surgical area to deliver the therapeutic properties of AmnioGuard.

See AmnioGuard Product Insert

AmnioGuard can be used for a variety of indications including:

  • Shunt Tube Exposure Prevention
  • Scleral Melt/Ischemia
  • Fornix & Socket Reconstruction
  • Marginal Entropion Repair
  • Removal of Tumors or Lesions
  • Symblepharon
  • Descemetocele or Perforation
  • Ocular Dermal Wounds
  • Limbal Tumors Surface Reconstruction

BioTissue Ocular Customer Support:

Call us Monday – Friday: 9:00 a.m. to 7:00 p.m. Eastern Standard Time.

Email: [email protected]
Call: (888) 296-8858
Fax: (305) 412-4429

For more information, visit our Ordering page.

Download AmnioGuard Product Information

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The time is now to achieve a new standard of care. Together, we can make a difference in eye care management.

Frequently Asked Questions

Can AmnioGuard be used as an alternative to commonly used Autograft and Allograft?

AmnioGuard is a beneficial alternative to other commonly used grafts. However, it could be used in combination with a mucosal graft to deliver a premium outcome. In contrast to Autograft such as mucosal graft, other allografts available are dehydrated in nature and don’t retain the tensile strength and many of the key biologics responsible for facilitating healing.

How can AmnioGuard be used in the ocular surface reconstruction procedures?

AmnioGuard can be either sutured (using an 8-0 Vicryl suture) or glued (fibrin glue), or both to the surrounding conjunctiva and underlying sclera. Fibrin glue can shorten the surgery time and decrease conjunctival inflammation and discomfort.

What are some of the disadvantages of autologous substitute graft?

The disadvantages of autologous substitute grafts include an undesirable cosmetic appearance, foul discharge, graft harvesting, donor-site morbidity, and contraction of the graft.

Sheha H, Tello C, Al-Aswad L, Sayed M, Lee R. Outcomes of the Shunt Tube Exposure Prevention Study (STEPS), a randomized clinical trial. Opthalmol Glaucoma. [Online] August 16, 2019.
Finger PT, Jain P, Mukkamala SK. Super-thick amniotic membrane for ocular surface reconstruction. Am J Opthalmol. 2019;198:45-53.
Slentz, D. and Nelson, C. (2019). Novel Use of Cryopreserved Ultra-thick Human Amniotic Membrane for Management of Anophthalmic Socket Contracture. Ophthalmic Plastic and Reconstructive Surgery, 35(2), pp.193-196.
Johnson, Amy, et al. “Understanding the impact of preservation methods on the integrity and functionality of placental allografts.” Annals of plastic surgery 79.2 (2017): 203-213.
Tighe S, Mead O, Lee A and Tseng S. Basic Science Review of Birth Tissue Uses in Ophthalmology. Taiwan Journal of Ophthalmology. 2020; 10.