Healing Vision. Restoring Life.

Early intervention is critical in eye care. Prokera® corneal bandages are designed for treating damaged corneas by creating an environment for regenerative healing. Prokera helps expedite and empower the eye’s healing abilities for better patient outcomes. 


Seeing a Difference

Our proprietary CryoTek® cryopreservation process maintains full biologic components including a key protein complex HC-HA/PTX3, and structural integrity equivalent to fresh tissue, which helps rapidly restore the cornea’s own healing capabilities.1,2

Prokera excels at restoring a normal and healthy epithelium while minimizing the risk of scar tissue formation. Heat dehydrated amniotic membrane grafts are processed in a way that destroys crucial biologic components, increasing the risks for repeated epithelial defects or erosions, chronic inflammation, scarring, vision loss, or pain.3,4

Integration Made Easy  

Prokera can be easily incorporated into any eye care practice to optimize outcomes.

  • Can be easily placed during a regular office visit or used with surgical interventions
  • May reduce the need for additional patient visits with slow or poor healing
  • Medical device classification ensures high reimbursement
  • Average Medicare reimbursement: $1,458
  • Minimizes a patient’s cost-burden of treatment
  • Easy-to-use packaging
  • Conveniently stored in any on-site refrigerator or freezer
Product Family
  • Product Family
  • Packaging & Storage
  • Application Guide
  • Resources
  • Customer Support
  • Product Family
  • Packaging & Storage
  • Application Guide
  • Resources
  • Customer Support

The Right Healing. The Right Product.

Prokera Classic

Maintains orbital space with a symblephoron ring for cases where prevention of closure or adhesion is a concern.

Prokera Slim

Uses ComfortRing™ technology for a lower profile device that contours to the ocular surface to maintain comfort in treatment.

Prokera Plus

Maximizes the therapeutic benefit with a double layer of cryopreserved amniotic membrane tissue, for patients who need intensive treatment.

Prokera Clear

Provides patient with visual acuity during treatment with a 6mm ClearView™ aperture, which is crucial in monocular needs.

BioTissue products (Prokera, AmnioGraft, & AmnioGuard) are shipped in a temperature-controlled container and can be kept in the shipping container until the marked expiration date/time. Once removed from the shipping container, the products should be stored in a refrigerator or freezer according to the following guidelines:

Location & Temperature

Unopened insulated shipping container

-80°C → 4°C (-112°F → 39.2°F)

Example: ultra-low temperature freezer, standard freezer, or standard refrigerator

Shelf Life

Use within the expiration date printed on the outer shipping box.

Use within the expiration date printed on product packaging (2 years from date of manufacture).

See Prokera Product Insert

Preparing Prokera for Use

  • Remove Prokera from inner pouch
  • Rinse Prokera thoroughly with sterile saline solution to prevent potential stinging from preservation media
  • Patient may experience a temporary foreign body sensation upon insertion
  • Download the Application Guide

BioTissue Ocular Customer Support:

Call us Monday – Friday: 9:00 a.m. to 7:00 p.m. Eastern Standard Time.

Email: [email protected]
Call: (888) 296-8858
Fax: (305) 412-4429

For more information, visit our Ordering page.

Download Prokera Product Information

To learn more about Prokera, fill out the details below:
By clicking the button below, I agree to receive marketing communications from BioTissue I am aware that I can unsubscribe at any time.
This field is for validation purposes and should be left unchanged.

“Before the Prokera I did not have crystal vision. Everything was blurry, had a hue to it, difficulty focusing on things. Now my vision is crystal clear, and I can see things I couldn’t see before. This is incredible. I’m just blown away.”

– Prokera Patient, Allentown, PA

Frequently Asked Questions

What is Prokera?

Prokera is made from amniotic membrane which has natural anti-inflammatory and anti-scarring properties. It is the only FDA cleared therapeutic device used by eye care practitioners to provide quick3 symptom relief and reduce inflammation associated with ocular surface disease. It helps restore your cornea and return your eye to a normal, healthy state.

What is amniotic membrane?

Amniotic membrane is part of the placenta and is the tissue closest to the baby throughout development in the womb. Amniotic membrane protects the baby from harm and has natural biologic properties which help the baby develop. The tissue has biological components that aid in ocular surface repair.

The amniotic membrane tissue in Prokera has natural therapeutic properties that help damaged eye surfaces heal. Eyes treated with Prokera have less scarring and less inflammation. The amniotic membrane in Prokera is thin and clear like the tissue on the surface of your eye and protects your eye’s damaged tissue while inserted.

Where does the amniotic membrane used in Prokera come from?

The tissue is donated by consenting healthy mothers after scheduled cesarean section (C-Section) births within the United States. Donor suitability is stringent and is determined through social, physical, and medical screening.

What does Prokera treat?

Prokera is used by eye doctors to treat eye diseases such as keratitis, corneal scars, chemical burns, corneal defects, partial limbal stem cell deficiency, and many other inflammatory ocular surface diseases.

Tan EK, Cooke M, Mandrycky C, et al. Structural and biological comparison of cryopreserved and fresh amniotic membrane tissues. J Biomater Tissue Eng. 2014;(4):379–388.
Cooke M, Tan EK, Mandrycky C, et al. Comparison of cryopreserved amniotic membrane and umbilical cord tissue with dehydrated amniotic membrane/chorion tissue. J Wound Care. 2014;23(10):4 65-476.
Desai NR. A comparison of cryopreserved amniotic membrane and bandage contact lens in their ability to provide high-quality healing after superficial keratectomy. Rev Ophthalmol. September 2014:1-6.
Rumpakis J. Amniotic membranes—the perfect cover. Rev Ophthalmol. April 2016:49-54.
Pachigolla G, Prasher P, Di Pascuale MA, et al. Evaluation of the role of PROKERA in the management of ocular surface and orbital disorders. Eye Contact Lens. 2009;35(4):172-175.
Morkin MI, Hamrah P. Efficacy of self-retained cryopreserved amniotic-membrane for treatment of neuropathic corneal pain. Ocul Surf. 2018;16(1):132-138.