Healing Traumatic Injuries is Urgent

BioTissue is the answer

Clarix® in Trauma

Traumatic injuries are challenging and expediting soft tissue healing is critical. Clarix 1K cryopreserved ultra-thick human birth tissue allografts can be used as an adjunct to help address soft tissue closure due to Trauma-related complications. Clarix has been shown to:

  • Manage inflammation1-4
  • Manage adhesion formation1-4
  • Expedite closure of the soft tissue envelope1-4

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Birth Tissue Applications

Clinical Catalog

Polytrauma Patient
  • Polytrauma Patient
  • Calcaneal Fracture
  • Forearm
  • Pilon Fracture
  • Polytrauma Patient
  • Calcaneal Fracture
  • Forearm
  • Pilon Fracture

Motor Vehicle Accident Polytrauma Patient

39-year-old male (smoker) involved in motor vehicle accident. Polytrauma patient presented with broken femur, tibia, and fibula with large posterior knee wound (11x9x4cm).

Case courtesy of Christopher Stewart, MD, Baptist Health, Little Rock, AR1

Foot fracture repaired through Open Reduction Internal Fixation (ORIF)

FIG. 1: Birth tissue placement over hardware after ORIF

FIG. 2: Wound healing at 2 weeks – controlled inflammation

FIG. 3: Wound healing at 6 weeks

Split Thickness Skin Graft vs. Human Birth Tissue Application

Split-thickness Skin Grafting (STSG) is a classic example where complete, functional healing can be challenging.

The forearm case on the right shows a comparison between a BioTissue human birth tissue application on the volar side (FIG. 1A) vs. a dorsal split thickness graft (FIG. 2A). Both the STSG, and birth tissue allograft wound sites, achieved closure within 2.5-months post-op. However, the medial side of the arm, where the allograft was utilized, showed a return of hair growth and normal sensation, without significant contracture (FIG. 1B), whereas the area covered by the STSG did not (FIG. 2B).

Case courtesy of Christopher Stewart, MD, Little Rock, AR

Achieved healing in 15-Weeks.

Birth Tissue Application in Lower Extremity Fracture

  • 54-year-old male who fell off a ladder at 12-14 feet and suffered a left grade 3A open pilon fracture.
  • Patient underwent 2 previous debridements, ex-fix, followed by ORIF for definitive stabilization.
  • At 6 weeks, the anterior medial side had 3×2.5cm full thickness tissue necrosis. After debridement, 8x3cm UC was placed deep in the tunneling wound with exposed bone and over the wounds with adjunctive VAC for 3 days.
  • Wound had progressive healing and completely closed by 4 months.

Courtesy of Dr Stewart MD (Little Rock, AR)

Dr. Stewart shares how human birth tissue has revolutionized his traumatic patient care.

Dr. Stewart shares his findings after performing an economic evaluation comparing the average cost savings per patient and additional costs incurred from time off work over a 5-year period in the birth tissue patient cohort vs. the control (Presented at the 2022 AOFAS Annual Meeting).

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The timing of treatment is critical in traumatic injuries.  

At the time of surgery, give that one chance its best chance.

References
Stewart CM. The Use of Cryopreserved Umbilical Cord in Open Reduction and Internal Fixation of Calcaneal Fractures. SunKrist J Trauma Emerg Med Acute Care. 2019;1(1):1-6.
Bemenderfer TB, Anderson RB, Odum SM, Davis WH. Effects of Cryopreserved Amniotic Membrane-Umbilical Cord Allograft on Total Ankle Arthroplasty Wound Healing. J Foot Ankle Surg. 2019 Jan;58(1):97-102. doi: 10.1053/j.jfas.2018.08.014. PMID: 30583786.
Warner M, Lasyone L. An Open-label, Single-center, Retrospective Study of Cryopreserved Amniotic Membrane and Umbilical Cord Tissue as an Adjunct for Foot and Ankle Surgery. Surg Technol Int. 2014 Nov;25:251-5. PMID: 25396324.
Ellington JK, Ferguson CM. The use of amniotic membrane/umbilical cord in first metatarsophalangeal joint cheilectomy: a comparative bilateral case study. Surg Technol Int. 2014 Nov;25:63-7. PMID: 25396321.